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Breakthrough Medicine

Fighting cancer. Curing tremors. Developing drugs. Stemming addictions. Transplanting hands. Treating aneurysms. It’s all in a day’s work for these pioneering Minnesota doctors and researchers.



(page 1 of 3)

Aviva Abosch

University of Minnesota
Department of Neurosurgery

Dressed in blue scrubs, a surgical mask, and two pairs of rubber gloves, Dr. Aviva Abosch stands with hunched shoulders over the patient on the table in front of her, preparing to slice into his skull and peer deep into his brain.

She jokes about needing a latté and a lunch break. Then, with six nurses and technicians bustling around her, the 48-year-old neurosurgeon makes an incision into the shaved surface of her patient’s head and pulls back the pink skin like a banana peel, revealing a nickel-sized hole that had already been drilled into the skull during a previous surgery. With steady hands under two massive surgical lights, Abosch pulls out a dysfunctional, one-millimeter-wide wire. Guided by a large metal head frame, which Abosch spent an hour setting up with precision before the surgery, a new wire fitted with four electrodes begins its slow and steady path into the man’s gray brain tissue.

Nearly two hours into the procedure, known as deep-brain stimulation, Abosch moves to a computer monitor and dims the lights in the green-tiled room. With her right hand on the mouse, she watches a skinny red line squiggle up and down on the screen, and she listens to wavering static that resembles someone trying to find a station on an AM radio dial. In fact, the noise is the sound of brain cells firing as the wire moves past them. The pattern of the cellular firing gives the surgeon a clue as to what brain structure the wire is passing through on the way to its target: an almond-sized structure called the subthalamic nucleus.

Abosch suspects excessive firing of nerves in the subthalamic nucleus has been causing a form of involuntary shaking, known as essential tremor—a source of frustration for the patient, a man in his 60s who works as the head painter on a nearby college campus. Once activated, the implanted device will send a series of ongoing electrical impulses to this region of the brain, with the goal of reducing the tremor.

“You awake, Gene? You hear all that noise? That’s your brain working,” Abosch says from her seat by the man’s feet. Suddenly, the speakers squawk loudly as if air is slowly draining from a balloon. “That’s an injured cell, Gene. You’ve got bajillions of those. Don’t cry over the loss of that one cell.”

Abosch’s operating manner is remarkably relaxed, considering she is probing the brain of a conscious patient. But for her, the procedures of deep-brain stimulation (DBS) are routine. She has done more than 250 DBS surgeries for patients with Parkinson’s disease, essential tremor, and related movement disorders since she arrived at the University of Minnesota in 2005.

In addition to the electrodes that are placed directly into the brain, DBS involves a pacemaker-like battery that goes inside the chest and a wire that snakes its way beneath the skin along the neck and behind the ear from battery to electrodes. Doctors program the device to deliver just the right amount of stimulation. Patients remain awake during implantation so that surgeons can make sure they’ve struck the right location. It may sound agonizing, but brain cells have no pain receptors, which means the patient doesn’t feel the wire going in.

As easy as she makes it look, probing the depths of the human brain isn’t necessarily what Abosch thought she would end up doing, even after she left her childhood home in suburban Buffalo for Bryn Mawr College in Pennsylvania and became interested in cognition. As an undergraduate in the early 1980s, she was fascinated by the question of what makes people different from other animals, which drove her to take a psychology course. But the class lacked any mention of how one’s sense of self worked on a fundamental level, and Abosch found the course to be unsatisfying. Instead, she turned to neuroscience, earning both an MD and a PhD at the University of Pittsburgh, where she figured she’d follow in the footsteps of her advisers and study brain development in children.

It was during a two-week rotation in neurosurgery that she had her first medical revelation—and a glimpse into her unexpected future. “It was wild,” she says. “You’re actually standing there in the operating room, you see the brain, and you see what makes us different [from animals]. I didn’t get any closer to understanding it, but it was an epiphany.”

Aviva Abosch
PHOTO BY DAVID J. TURNER (10)

Abosch’s first exposure to deep-brain stimulation came during her residency at the University of San Francisco, where in the late-90s, she worked under a surgeon who was using what was then a new, cutting-edge approach to treating movement disorders. DBS was developed in Europe in 1987. But it wasn’t until 1997—a few years after Abosch arrived in San Francisco—that DBS was approved in the United States for treating essential tremor. Approval for Parkinson’s and dystonia followed in 2002 and 2003. Since then, results have been so spectacular for muting these diseases that Abosch and colleagues are now moving into ambitious new applications. She recently treated two patients with obsessive-compulsive disorder—with hopeful, if preliminary, results.

Now, she is starting work on a clinical trial for patients with depression who haven’t responded to any other treatments, including antidepressants or electroshock therapy. Eventually, as part of the double-blinded, controlled trial, Abosch’s team will treat 15 patients with recalcitrant depression, though neither she nor the patients (nor participants undergoing the same procedure at other institutions) will be told if their implants have been activated, thus removing concerns about placebo effects or biased interpretations of results. If the technique proves effective—and there is reason to believe that it will, based on imaging studies that show hyperactivity in a part of the brain called the subgenual cingulate white matter in some people with major depression—the sky may be the limit. Researchers are discussing the possibility of using DBS to treat just about any disease that has roots in the brain, including Tourette’s syndrome, morbid obesity, eating disorders, Alzheimer’s disease, memory loss, paralysis, and more.

For a procedure with such dramatic successes and so many hopes riding on it, though, we still know surprisingly little about how DBS actually works in the brain, says neurosurgeon Kendall Lee, director of the Neural Engineering Laboratory at the Mayo Clinic in Rochester. The foundations for the treatment were actually discovered by accident about 60 years ago, during an operation on a man with Parkinson’s disease. Previously, surgeons had treated Parkinson’s patients by cutting out entire sections of the brain. The method stopped tremors, but it also prevented other kinds of movements, often leaving parts of the body permanently paralyzed, among other side effects.

In 1951, a Mayo surgeon named Irving Cooper tore an artery at the beginning of a surgery on patient with Parkinson’s. After stemming the bleeding, repairing the damage, and aborting surgery, Cooper was surprised to find that his patient awoke not only mobile, but also free of tremors. It was a lightbulb-sparking event that gave surgeons a much more detailed picture of where in the brain certain problems originate, Lee says. Since then, doctors have zeroed in on more specific areas in the thalamus, sub-thalamus, and other regions near the center of the brain that are linked to various neurological disorders. And they have discovered that electrical stimulation can work like brain lesions, altering activity in localized regions—if carefully placed, for the better.

In one of the latest steps toward understanding the details of how DBS actually works, Lee’s group and others have found that electrical stimulation leads to a release of neurotransmitters, the messenger molecules that allow individual nerve cells to communicate with each other inside the brain. The Mayo team has also designed a device that can wirelessly monitor neurotransmitter levels during DBS. With advances like these, the hope is to create “smarter” DBS devices that could alter levels of stimulation as needed. Even if the device could just recognize when a patient is asleep, it would be a major step forward, Abosch says. That way, doctors wouly only have to replace batteries every nine years instead of every three. “Right now, we’re doing electroshock therapy for a lot of psychiatric diseases,” Lee says. “But rather than shocking the whole brain, with DBS we can do more focal treatments. Electroshock therapy is like a shotgun approach where you shoot everything. DBS is more like a rifle.”

After more than four hours in the operating room without a break, Abosch and her team are ready to test the electrodes they’ve placed in the patient’s brain. Earlier that morning, before the new device was in place, his left arm swung wildly when nurses challenged him to draw a spiral on a piece of paper and then write his name. The spiral looked more like a squiggle. The letters looked like they came from the hand of a three-year old. After activation, however, Gene draws concentric circles, drinks steadily from a cup, and keeps his left hand still while holding some papers.

Watching patients witness their own swift and drastic improvement remains an emotional experience, even after several hundred surgeries, Abosch says. “When you have a patient who has dealt with a tremor for 30 years of his or her life and you stop the tremor suddenly and they get all choked up or burst into tears, it’s moving,” she says. “You’ll see patients during the procedure suddenly reach up and look at their hand. And it becomes apparent to you watching the patient that they suddenly realize something is profoundly better. That is a touching moment.”
 

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MN Events Calendar Sponsored by:

July 2015

No Events

July 6 – July 17, 9am-4pm Academy of Russian Ballet Summer Dance Programs offer comprehensive training in Russian classical ballet technique (Vaganova syllabus) and skills...

Cost: $650.00-$850.00

Where:
Academy of Russian Ballet
14675 Martin Drive
Eden Prairie, MN  55344
View map »


Sponsor: Academy of Russian Ballet
Telephone: 612 501 9208
Contact Name: Kirill Bak
Website »

More information

July 7 – July 18 Academy of Russian Ballet Summer Dance Programs offer comprehensive training in Russian classical ballet technique (Vaganova syllabus) and skills development. For four...

Cost: $300-$800

Where:
Academy of Russian Ballet
14675 Martin Drive
Eden Prairie, MN  55344
View map »


Sponsor: Academy of Russian Ballet
Telephone: 612 501 9208
Contact Name: Kirill Bak
Website »

More information

Local residents will have their shot at fame as the Aha Moment Tour makes its way to St. Paul. The Aha Moment Tour features a one-of-a-kind mobile television studio in a 34’...

Cost: Free

Where:
Raspberry Island
Mississippi National River and Recreation Area
St. Paul, MN  55107
View map »


Sponsor: Mutual of Omaha

More information

THE BIG EPIC SHOW presents our BIG EPIC SUMMER ENTERTAINMENT ARTS CAMP, where you will learn the fundamentals of writing and performing sketch comedy, live hip-hop, and professionally choreographed...

Cost: $125

Where:
Bloomington Kennedy High School
9701 Nicollet Ave S
Bloomington, MN  55420
View map »


Sponsor: THE BIG EPIC SHOW
Telephone: 952-913-8412
Contact Name: Cherice Mahal
Website »

More information

THE BIG EPIC SHOW presents our BIG EPIC SUMMER ENTERTAINMENT ARTS CAMP, where you will learn the fundamentals of writing and performing sketch comedy, live hip-hop, and professionally choreographed...

Cost: $125

Where:
Kennedy Senior High School
9701 Nicollet Ave S
Bloomington, MN  55420
View map »


Sponsor: THE BIG EPIC SHOW
Telephone: 952-913-8412
Contact Name: Cherice Mahal
Website »

More information

Celebrate the importance of clean water with this free, family-friendly event.  Discover how water works, what lives in it, how much we all need it, and how we can take care of it.  Enjoy...

Cost: Free

Where:
Jay C, Hormel Nature Center
1304 21st St NE
Austin, MN  55912
View map »


Sponsor: Jay C, Hormel Nature Center
Telephone: 507-437-7519
Contact Name: Larry Dolphin
Website »

More information

Show More...
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July 7 – July 18 Academy of Russian Ballet Summer Dance Programs offer comprehensive training in Russian classical ballet technique (Vaganova syllabus) and skills development. For four...

Cost: $300-$800

Where:
Academy of Russian Ballet
14675 Martin Drive
Eden Prairie, MN  55344
View map »


Sponsor: Academy of Russian Ballet
Telephone: 612 501 9208
Contact Name: Kirill Bak
Website »

More information

July 6 – July 17, 9am-4pm Academy of Russian Ballet Summer Dance Programs offer comprehensive training in Russian classical ballet technique (Vaganova syllabus) and skills...

Cost: $650.00-$850.00

Where:
Academy of Russian Ballet
14675 Martin Drive
Eden Prairie, MN  55344
View map »


Sponsor: Academy of Russian Ballet
Telephone: 612 501 9208
Contact Name: Kirill Bak
Website »

More information

Local residents will have their shot at fame as the Aha Moment Tour makes its way to St. Paul. The Aha Moment Tour features a one-of-a-kind mobile television studio in a 34’...

Cost: Free

Where:
Raspberry Island
Mississippi National River and Recreation Area
St. Paul, MN  55107
View map »


Sponsor: Mutual of Omaha

More information

THE BIG EPIC SHOW presents our BIG EPIC SUMMER ENTERTAINMENT ARTS CAMP, where you will learn the fundamentals of writing and performing sketch comedy, live hip-hop, and professionally choreographed...

Cost: $125

Where:
Bloomington Kennedy High School
9701 Nicollet Ave S
Bloomington, MN  55420
View map »


Sponsor: THE BIG EPIC SHOW
Telephone: 952-913-8412
Contact Name: Cherice Mahal
Website »

More information

THE BIG EPIC SHOW presents our BIG EPIC SUMMER ENTERTAINMENT ARTS CAMP, where you will learn the fundamentals of writing and performing sketch comedy, live hip-hop, and professionally choreographed...

Cost: $125

Where:
Kennedy Senior High School
9701 Nicollet Ave S
Bloomington, MN  55420
View map »


Sponsor: THE BIG EPIC SHOW
Telephone: 952-913-8412
Contact Name: Cherice Mahal
Website »

More information

As Urban Homeworks celebrates 20 years of People Oriented Development, we want to invite you to participate in some of the deep-rooted, heart-changing, narrative shifting conversations that have...

Cost: FREE

Where:
The Capri Theater
2027 W Broadway Ave
Minneapolis, MN  55411
View map »


Sponsor: Urban Homeworks
Telephone: 712-830-7826
Contact Name: Emily Halstead
Website »

More information

Celebrate the importance of clean water with this free, family-friendly event.  Discover how water works, what lives in it, how much we all need it, and how we can take care of it.  Enjoy...

Cost: Free

Where:
Jay C, Hormel Nature Center
1304 21st St NE
Austin, MN  55912
View map »


Sponsor: Jay C, Hormel Nature Center
Telephone: 507-437-7519
Contact Name: Larry Dolphin
Website »

More information

Show More...
Show Less...

July 7 – July 18 Academy of Russian Ballet Summer Dance Programs offer comprehensive training in Russian classical ballet technique (Vaganova syllabus) and skills development. For four...

Cost: $300-$800

Where:
Academy of Russian Ballet
14675 Martin Drive
Eden Prairie, MN  55344
View map »


Sponsor: Academy of Russian Ballet
Telephone: 612 501 9208
Contact Name: Kirill Bak
Website »

More information

July 6 – July 17, 9am-4pm Academy of Russian Ballet Summer Dance Programs offer comprehensive training in Russian classical ballet technique (Vaganova syllabus) and skills...

Cost: $650.00-$850.00

Where:
Academy of Russian Ballet
14675 Martin Drive
Eden Prairie, MN  55344
View map »


Sponsor: Academy of Russian Ballet
Telephone: 612 501 9208
Contact Name: Kirill Bak
Website »

More information

THE BIG EPIC SHOW presents our BIG EPIC SUMMER ENTERTAINMENT ARTS CAMP, where you will learn the fundamentals of writing and performing sketch comedy, live hip-hop, and professionally choreographed...

Cost: $125

Where:
Kennedy Senior High School
9701 Nicollet Ave S
Bloomington, MN  55420
View map »


Sponsor: THE BIG EPIC SHOW
Telephone: 952-913-8412
Contact Name: Cherice Mahal
Website »

More information

THE BIG EPIC SHOW presents our BIG EPIC SUMMER ENTERTAINMENT ARTS CAMP, where you will learn the fundamentals of writing and performing sketch comedy, live hip-hop, and professionally choreographed...

Cost: $125

Where:
Bloomington Kennedy High School
9701 Nicollet Ave S
Bloomington, MN  55420
View map »


Sponsor: THE BIG EPIC SHOW
Telephone: 952-913-8412
Contact Name: Cherice Mahal
Website »

More information

Patagonia in St. Paul (1648 Grand Ave, 651-698-1703) hosts Cameron Chambers for an evening of stories from his new fly fishing book, Chasing Rumor. Hear about his modern-day pilgrimage to the...

Cost: Free

Where:
Patagonia St. Paul
1648 Grand Ave
Saint Paul, MN  55105
View map »


Website »

More information

Celebrate the importance of clean water with this free, family-friendly event.  Discover how water works, what lives in it, how much we all need it, and how we can take care of it.  Enjoy...

Cost: Free

Where:
Jay C, Hormel Nature Center
1304 21st St NE
Austin, MN  55912
View map »


Sponsor: Jay C, Hormel Nature Center
Telephone: 507-437-7519
Contact Name: Larry Dolphin
Website »

More information

Show More...
Show Less...

Consumers are rejecting traditional marketing at an alarming rate. By fast-forwarding past commercials using DVR and reading publications online, therefore never seeing your print ads,...

Cost: Free to attend, continental breakfast provided

Where:
Dakota Jazz Club
1010 Nicollet Mall
Minneapolis, MN  55401
View map »


Telephone: 612-204-1919

More information

July 6 – July 17, 9am-4pm Academy of Russian Ballet Summer Dance Programs offer comprehensive training in Russian classical ballet technique (Vaganova syllabus) and skills...

Cost: $650.00-$850.00

Where:
Academy of Russian Ballet
14675 Martin Drive
Eden Prairie, MN  55344
View map »


Sponsor: Academy of Russian Ballet
Telephone: 612 501 9208
Contact Name: Kirill Bak
Website »

More information

July 7 – July 18 Academy of Russian Ballet Summer Dance Programs offer comprehensive training in Russian classical ballet technique (Vaganova syllabus) and skills development. For four...

Cost: $300-$800

Where:
Academy of Russian Ballet
14675 Martin Drive
Eden Prairie, MN  55344
View map »


Sponsor: Academy of Russian Ballet
Telephone: 612 501 9208
Contact Name: Kirill Bak
Website »

More information

THE BIG EPIC SHOW presents our BIG EPIC SUMMER ENTERTAINMENT ARTS CAMP, where you will learn the fundamentals of writing and performing sketch comedy, live hip-hop, and professionally choreographed...

Cost: $125

Where:
Kennedy Senior High School
9701 Nicollet Ave S
Bloomington, MN  55420
View map »


Sponsor: THE BIG EPIC SHOW
Telephone: 952-913-8412
Contact Name: Cherice Mahal
Website »

More information

THE BIG EPIC SHOW presents our BIG EPIC SUMMER ENTERTAINMENT ARTS CAMP, where you will learn the fundamentals of writing and performing sketch comedy, live hip-hop, and professionally choreographed...

Cost: $125

Where:
Bloomington Kennedy High School
9701 Nicollet Ave S
Bloomington, MN  55420
View map »


Sponsor: THE BIG EPIC SHOW
Telephone: 952-913-8412
Contact Name: Cherice Mahal
Website »

More information

WCCO’s “Goin’ to the Lake” live radio and TV broadcasts are coming to Big Sandy Lake on July 9 & 10 (Thursday-Friday). Join the team as they discover all the summer fun...

Cost: Free

Where:
Big Sandy Lodge and Resort
20534 487th Street
McGregor, MN  55760
View map »


Sponsor: Big Sandy Lodge and Resort
Telephone: 218-426-5040
Website »

More information

Summer Faire Announces Its 2015 Season! The Shoppes at Arbor Lakes’ popular summer concert series is back- better than ever! Don’t miss FREE live music from talented local...

Cost: FREE

Where:
The Shoppes Central Courtyard
I-94/I-694 at Hemlock Lane
Maple Grove, MN
View map »


Sponsor: The Shoppes
Telephone: 763-488-9965
Contact Name:
Website »

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In space, no one can hear you scream. But, can they hear you laugh? Probably not, which is unfortunate because you will be doing a lot of it during this show. So set your phasers to hilarity and...

Cost: $12 at the door, $10 if purchased in advance or with fringe button

Where:
Bryant Lake Bowl
810 West Lake Street
Minneapolis, MN  55408
View map »


Sponsor: Comedy Fiends
Telephone: 320-493-0769
Contact Name: William Sommers
Website »

More information

Girl Friday Productions presents THE MATCHMAKER by Thornton Wilder, July 10-26, on the new Andy Boss Thrust Stage at Park Square Theatre. Wilder’s hilarious farce about love, money and...

Cost: $25 with discounts for MPR members, students, seniors, group, fringe buttons

Where:
Park Square Theatre
20 West Seventh Place
Historic Hamm Building
St. Paul, MN  55102
View map »


Sponsor: Girl Friday Productions
Telephone: 651-291-7005
Contact Name: Kirby Bennett
Website »

More information

Yee haw! Pull on your boots and dust off your hat! The 35th Annual Hamel Rodeo and Bull Ridin’ Bonanza stampedes into Cocoran Lions Park July 9-12.  It’s bronc...

Cost: ranges from $9 to $18

Where:
Corcoran Lions Park
19101 County Road 10
Corcoran, MN  55340
View map »


Sponsor: Farmers State Bank of Hamel
Telephone: 763.478.6611
Contact Name: Shorty Dorweiler
Website »

More information

All Originals Jazz Series presents the James Buckley Trio: James Buckley, bass; JT Bates, drums; Bryan Nichols, piano. All Originals is a weekly jazz concert series at Studio Z featuring select...

Cost: $10

Where:
Studio Z
275 E. 4th Street, Suite 200
St. Paul, MN  55101
View map »


Sponsor: Studio Z
Telephone: 651-755-1600
Website »

More information

The Instinct Gallery presents: An evening of performance and video on Nicollet Mall with: The BodyCartography Project and Sean Smuda 8 PM Please join the BodyCartography Project as they...

Cost: Free

Where:
Instinct Art Gallery
940 Nicollet Mall
Minneapolis, MN  55403
View map »

More information

Celebrate the importance of clean water with this free, family-friendly event.  Discover how water works, what lives in it, how much we all need it, and how we can take care of it.  Enjoy...

Cost: Free

Where:
Jay C, Hormel Nature Center
1304 21st St NE
Austin, MN  55912
View map »


Sponsor: Jay C, Hormel Nature Center
Telephone: 507-437-7519
Contact Name: Larry Dolphin
Website »

More information

Show More...
Show Less...

July 6 – July 17, 9am-4pm Academy of Russian Ballet Summer Dance Programs offer comprehensive training in Russian classical ballet technique (Vaganova syllabus) and skills...

Cost: $650.00-$850.00

Where:
Academy of Russian Ballet
14675 Martin Drive
Eden Prairie, MN  55344
View map »


Sponsor: Academy of Russian Ballet
Telephone: 612 501 9208
Contact Name: Kirill Bak
Website »

More information

July 7 – July 18 Academy of Russian Ballet Summer Dance Programs offer comprehensive training in Russian classical ballet technique (Vaganova syllabus) and skills development. For four...

Cost: $300-$800

Where:
Academy of Russian Ballet
14675 Martin Drive
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View map »


Sponsor: Academy of Russian Ballet
Telephone: 612 501 9208
Contact Name: Kirill Bak
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Contact Name: Cherice Mahal
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More information

THE BIG EPIC SHOW presents our BIG EPIC SUMMER ENTERTAINMENT ARTS CAMP, where you will learn the fundamentals of writing and performing sketch comedy, live hip-hop, and professionally choreographed...

Cost: $125

Where:
Kennedy Senior High School
9701 Nicollet Ave S
Bloomington, MN  55420
View map »


Sponsor: THE BIG EPIC SHOW
Telephone: 952-913-8412
Contact Name: Cherice Mahal
Website »

More information

WCCO’s “Goin’ to the Lake” live radio and TV broadcasts are coming to Big Sandy Lake on July 9 & 10 (Thursday-Friday). Join the team as they discover all the summer fun...

Cost: Free

Where:
Big Sandy Lodge and Resort
20534 487th Street
McGregor, MN  55760
View map »


Sponsor: Big Sandy Lodge and Resort
Telephone: 218-426-5040
Website »

More information

Summer at the Civic: Free Friday Concerts Patio and Grill open at 4pm, Happy Hour 4 – 6pm, Music at 5:30 – 9pm Free admission.  Rain or shine. Fresh food & cold drinks....

Cost: Free

Where:
Rochester Civic Theatre
20 Civic Center Dr. SE
Rochester, MN  55904
View map »


Sponsor: 507 Magazine
Website »

More information

Summer Faire Announces Its 2015 Season! The Shoppes at Arbor Lakes’ popular summer concert series is back- better than ever! Don’t miss FREE live music from talented local...

Cost: FREE

Where:
The Shoppes Central Courtyard
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View map »


Sponsor: The Shoppes
Telephone: 763-488-9965
Contact Name:
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Cost: $12 at the door, $10 if purchased in advance or with fringe button

Where:
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Sponsor: Comedy Fiends
Telephone: 320-493-0769
Contact Name: William Sommers
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Girl Friday Productions presents THE MATCHMAKER by Thornton Wilder, July 10-26, on the new Andy Boss Thrust Stage at Park Square Theatre. Wilder’s hilarious farce about love, money and...

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View map »


Sponsor: Girl Friday Productions
Telephone: 651-291-7005
Contact Name: Kirby Bennett
Website »

More information

Yee haw! Pull on your boots and dust off your hat! The 35th Annual Hamel Rodeo and Bull Ridin’ Bonanza stampedes into Cocoran Lions Park July 9-12.  It’s bronc...

Cost: ranges from $9 to $18

Where:
Corcoran Lions Park
19101 County Road 10
Corcoran, MN  55340
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Sponsor: Farmers State Bank of Hamel
Telephone: 763.478.6611
Contact Name: Shorty Dorweiler
Website »

More information

TC is very excited for the return of... Eptic [Belgium] https://soundcloud.com/eptic https://www.facebook.com/eptic & Bear Grillz https://soundcloud.com/itsbeargrillz...

Cost: $15/ $20 @ door

Where:
The Loft @ Skyway Theatre
711 Hennepin Ave
Minneapolis, MN  55403
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More information

The Twin Cities are very excited for the return of... Eptic [Belgium] https://soundcloud.com/eptic https://www.facebook.com/eptic & Bear Grillz...

Cost: $15/$20

Where:
The Loft @ Skyway Theatre
711 Hennepin Avenue
Minneapolis, MN  55403
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Telephone: 612-333-6100
Website »

More information

Celebrate the importance of clean water with this free, family-friendly event.  Discover how water works, what lives in it, how much we all need it, and how we can take care of it.  Enjoy...

Cost: Free

Where:
Jay C, Hormel Nature Center
1304 21st St NE
Austin, MN  55912
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Sponsor: Jay C, Hormel Nature Center
Telephone: 507-437-7519
Contact Name: Larry Dolphin
Website »

More information

Beer aficionados can sample flavorful pours from the best regional brewers and watch live entertainment by a local Duluth band, Big Dave and the Ripples.  Lodging and beer fest packages are...

Cost: $29/advance, $40/door

Where:
Lutsen Mountains
445 Ski Hill Road
Lutsen, MN  80549
View map »


Sponsor: Visit Cook County
Telephone: 218-387-2788
Contact Name: Kjesti Vick
Website »

More information

COOK COUNTY, Minn., (June 16, 2015) – Northwest of the Coolest Small Town in America of Grand Marais, Tour de Fox, a program of the Michael J. Fox Foundation, is inviting teams to climb Eagle...

Cost: Donation

Where:
Grand Marais, MN


Sponsor: Visit Cook County
Telephone: 218-387-2788
Contact Name: Kjesti Vick
Website »

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On July 11, we'll hike up to the top of Eagle Mountain in northern Minnesota as part of the High Hopes Challenge, a summer-long quest to reach the high point in every state! Proceeds from this...

Cost: $50

Where:
Eagle Mountain, Minnesota
, MN


Sponsor: Foundation for Cancer Care in Tanzania
Telephone: 612-790-4549
Contact Name: Matea Wasend
Website »

More information

The 81st Annual Hopkins Raspberry Festival® will take place the third week of July in various locations throughout the City of Hopkins. Events are family-friendly and include: Royalty...

Cost: 0.00

Where:
Hopkins, MN  55343

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  The St. Paul Gus Macker 3on3 Basketball Event (StpMacker15) is ready for the second year back in St. Paul. American Royalty Group (ARG) & The Gus Macker Planning Committees (GM...

Cost: $160.00

Where:
Minnesota State Capitol
75 Dr. Rev Martin Luther King Jr. Blvd
Saint Paul, MN  55105
View map »


Sponsor: American Royalty Group
Telephone: 651-200-5708
Contact Name: Orlando Walker
Website »

More information

Swim, bike, and run in the Lifetime Tri Minneapolis to support St. Jude Children's Research Hospital. Participate as an individual or compete in the St. Jude Corporate Team Challenge for the...

Cost: Multiple Entry Point Levels

Where:
Lake Nokomis
Lake Nokomis
Minneapolis, MN  55417
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Telephone: 952-893-0442
Contact Name: Matthew O'Shea
Website »

More information

July 6 – July 17, 9am-4pm Academy of Russian Ballet Summer Dance Programs offer comprehensive training in Russian classical ballet technique (Vaganova syllabus) and skills...

Cost: $650.00-$850.00

Where:
Academy of Russian Ballet
14675 Martin Drive
Eden Prairie, MN  55344
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Sponsor: Academy of Russian Ballet
Telephone: 612 501 9208
Contact Name: Kirill Bak
Website »

More information

  ART AT ST. KATE’S the exciting 8th annual ART FAIR of local artists presented by Artists’ Circle and Textile Center   Art at St. Kate’s, a juried art fair of...

Cost: free

Where:
St. Catherine University
Randolph and Cleveland
Saint Paul, MN  55116
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Sponsor: Artists' Circle
Telephone: 651-222-2483
Contact Name: Marit Lee Kucera
Website »

More information

Hastings Prescott Area Arts Council and Friends of LeDuc will be sponsoring a home and garden show, "Sanctuaries - Homes, Churches, & Gardens." This event will feature 4...

Cost: Tickets are available at local businesses and online at www.hpaac.org

Where:
Hastings
, MN


Website »

More information

Let’s get started! Learn how to brew with the knowledgeable staff in a small group environment. You’ll brew a batch of beer so you can visually see the process from beginning to end....

Cost: Free

Where:
Northern Brewer
6021 Lyndale Ave S
Minneapolis, MN  55419
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Telephone: 612-843-4444
Website »

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Arts | Music | Food | Games A community arts festival celebrating arts for all ages! The community is invited together for an intergenerational day of art performances, artist...

Cost: FREE admission

Where:
Lyngblomsten
1415 Almond Avenue
St. Paul , MN  55108
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Groove to live jazz music with the vineyard as the backdrop of our first annual Jazz in July Festival. Bring your lawn chair or blanket and relax among the dragonflies, enjoying wine, beer,...

Cost: Free

Where:
Dancing Dragonfly Winery
2013 120th Avenue
St. Croix Falls, WI  54024
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Telephone: 715-483-9463
Website »

More information

Saturday, July 11, 2015 12 – 5 PM    The Shops at West End 1621 West End Boulevard St. Louis Park, MN   Come and discover the rapidly growing MN wine...

Cost: $25

Where:
The Shops at West End
1621 West End Boulevard
St. Louis Park, MN  55416
View map »


Website »

More information

Celebrate Bastille Day with the French! On Saturday the 11th, from 2 to 8 pm, Alliance Française and the Dakota will host an outdoor Bastille Day celebration. Stroll the West 7th Place...

Cost: $10, free for children under 12

Where:
West 7th Place Pedestrian Mall
Wabasha St N & 7th Place W
St Paul , MN  55101
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Sponsor: Alliance Française
Telephone: 612-332-0436
Website »

More information

THE BIG EPIC SHOW presents our BIG EPIC SUMMER ENTERTAINMENT ARTS CAMP, where you will learn the fundamentals of writing and performing sketch comedy, live hip-hop, and professionally choreographed...

Cost: $125

Where:
Bloomington Kennedy High School
9701 Nicollet Ave S
Bloomington, MN  55420
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Sponsor: THE BIG EPIC SHOW
Telephone: 952-913-8412
Contact Name: Cherice Mahal
Website »

More information

International Festival Burnsville! Burnsville is a city that truly values & celebrates cultural diversity! Join us at the eighth annual International Festival of Burnsville in...

Cost: Admission is Free!

Where:
Nicollet Commons Park
12550 Nicollet Avenue
Burnsville, MN  55337
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Sponsor: Dodge of Burnsville
Website »

More information

Summer Faire Announces Its 2015 Season! The Shoppes at Arbor Lakes’ popular summer concert series is back- better than ever! Don’t miss FREE live music from talented local...

Cost: FREE

Where:
The Shoppes Central Courtyard
I-94/I-694 at Hemlock Lane
Maple Grove, MN
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Sponsor: The Shoppes
Telephone: 763-488-9965
Contact Name:
Website »

More information

Saturday July 11th, 2015 Skyway Theatre is Excited to announce the 711 Festival Feat: **TROYBOI** (London) One of South East London's most closely guarded secrets...

Cost: $15/$20

Where:
The Loft
Minneapolis, MN

More information

Yee haw! Pull on your boots and dust off your hat! The 35th Annual Hamel Rodeo and Bull Ridin’ Bonanza stampedes into Cocoran Lions Park July 9-12.  It’s bronc...

Cost: ranges from $9 to $18

Where:
Corcoran Lions Park
19101 County Road 10
Corcoran, MN  55340
View map »


Sponsor: Farmers State Bank of Hamel
Telephone: 763.478.6611
Contact Name: Shorty Dorweiler
Website »

More information

Girl Friday Productions presents THE MATCHMAKER by Thornton Wilder, July 10-26, on the new Andy Boss Thrust Stage at Park Square Theatre. Wilder’s hilarious farce about love, money and...

Cost: $25 with discounts for MPR members, students, seniors, group, fringe buttons

Where:
Park Square Theatre
20 West Seventh Place
Historic Hamm Building
St. Paul, MN  55102
View map »


Sponsor: Girl Friday Productions
Telephone: 651-291-7005
Contact Name: Kirby Bennett
Website »

More information

TC is very excited for the return of... Eptic [Belgium] https://soundcloud.com/eptic https://www.facebook.com/eptic & Bear Grillz https://soundcloud.com/itsbeargrillz...

Cost: $15/ $20 @ door

Where:
The Loft @ Skyway Theatre
711 Hennepin Ave
Minneapolis, MN  55403
View map »

More information

Enjoy a free movie under the night sky! Big Sandy Lodge and Resort will be showing a film on their sand beach volleyball court at dusk on Saturday, July 11th (weather permitting). Bring a lawn...

Cost: Free

Where:
Big Sandy Lodge and Resort
20534 487th Street
McGregor, MN  55760
View map »


Sponsor: Big Sandy Lodge and Resort
Telephone: 218-426-5040
Website »

More information

Beer aficionados can sample flavorful pours from the best regional brewers and watch live entertainment by a local Duluth band, Big Dave and the Ripples.  Lodging and beer fest packages are...

Cost: $29/advance, $40/door

Where:
Lutsen Mountains
445 Ski Hill Road
Lutsen, MN  80549
View map »


Sponsor: Visit Cook County
Telephone: 218-387-2788
Contact Name: Kjesti Vick
Website »

More information

Over 70 local and regional artists set up by the glistening shores of Lake Superior for two days during the peak of summer to showcase their unique fine art and provide insight into their artistic...

Cost: Free

Where:
Grand Marais Art Colony
120 WEST 3RD AVENUE PO BOX 626
Grand Marais, MN  55604
View map »


Sponsor: 55604
Telephone: 218-387-2737
Website »

More information

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